2019

Hybrid Azo-Fluorophore Organic Nanoparticles as Emissive Turn-on Probes for Cellular Endocytosis.
Boucard J, Briolay T, Blondy T, Boujtita M, Nedellec S, Hulin P, Grégoire M, Blanquart C, Ishow E.
ACS Appl Mater Interfaces. 2019 Aug 19. doi: 10.1021/acsami.9b12989.

Pannexin-1 limits the production of proinflammatory cytokines during necroptosis.
Douanne T, André-Grégoire G, Trillet K, Thys A, Papin A, Feyeux M, Hulin P, Chiron D, Gavard J, Bidère N.
EMBO Rep. 2019 Aug 14:e47840. doi: 10.15252/embr.201947840.

gH625 Cell-Penetrating Peptide Promotes the Endosomal Escape of Nanovectorized siRNA in a Triple-Negative Breast Cancer Cell Line.
Ben Djemaa S, Hervé-Aubert K, Lajoie L, Falanga A, Galdiero S, Nedellec S, Soucé M, Munnier E, Chourpa I, David S, Allard-Vannier E.
Biomacromolecules. 2019 Aug 12;20(8):3076-3086. doi: 10.1021/acs.biomac.9b00637.

Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death.
Iradyan M, Iradyan N, Hulin P, Hambardzumyan A, Gyulkhandanyan A, Alves de Sousa R, Hessani A, Roussakis C, Bollot G, Bauvais C, Sakanyan V.
Cancers (Basel). 2019 Aug 1;11(8). pii: E1094. doi: 10.3390/cancers11081094.

In-vitro validation of 4D flow MRI measurements with an experimental pulsatile flow model.
David A, Le Touze D, Warin-Fresse K, Paul-Gilloteaux P, Bonnefoy F, Idier J, Moussaoui S, Guerin P, Serfaty JM.
Diagn Interv Imaging. 2019 Jan;100(1):17-23. doi: 10.1016/j.diii.2018.08.012

2018


Rat enteric glial cells express novel isoforms of Interleukine-7 regulated during inflammation.
Kermarrec L, Durand T, Gonzales J, Pabois J, Hulin P, Neunlist M, Neveu I, Naveilhan P.
Neurogastroenterol Motil. 2019 Jan;31(1):e13467. doi: 10.1111/nmo.13467. 

Immune Alterations in Patients With Type 1 Autoimmune Hepatitis Persist Upon Standard Immunosuppressive Treatment.
Renand A, Habes S, Mosnier JF, Aublé H, Judor JP, Vince N, Hulin P, Nedellec S, Métairie S, Archambeaud I, Brouard S, Gournay J, Conchon S.
Hepatol Commun. 2018 Aug 6;2(8):968-981. doi: 10.1002/hep4.1202.

Small Molecule-Based Fluorescent Organic Nanoassemblies with Strong Hydrogen Bonding Networks for Fine Tuning and Monitoring Drug Delivery in Cancer Cells.Boucard J, Linot C, Blondy T, Nedellec S, Hulin P, Blanquart C, Lartigue L, Ishow E.
Small. 2018 Aug 26:e1802307. doi: 10.1002/smll.201802307.

Human Motor Thalamus Reconstructed in 3D from Continuous Sagittal Sections with Identified Subcortical Afferent Territories.
Ilinsky I, Horn A, Paul-Gilloteaux P, Gressens P, Verney C, Kultas-Ilinsky K.
eNeuro. 2018 Jul 4;5(3). pii: ENEURO.0060-18.2018. doi: 10.1523/ENEURO.0060-18.2018. eCollection 2018 May-Jun

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.
Infante E, Castagnino A, Ferrari R, Monteiro P, Agüera-González S, Paul-Gilloteaux P, Domingues MJ, Maiuri P, Raab M, Shanahan CM, Baffet A, Piel M, Gomes ER, Chavrier P.
Nat Commun. 2018 Jun 22;9(1):2443. doi: 10.1038/s41467-018-04865-7.

Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma.
Nader JS, Abadie J, Deshayes S, Boissard A, Blandin S, Blanquart C, Boisgerault N, Coqueret O, Guette C, Grégoire M, Pouliquen DL.
Oncotarget. 2018 Mar 27;9(23):16311-16329. doi: 10.18632/oncotarget.24632. eCollection 2018 Mar 27.

A Biologist-Friendly Method to Analyze Cross-Correlation Between Protrusion Dynamics and Membrane Recruitment of Actin Regulators.
Paul-Gilloteaux P, Waharte F, Singh MK, Parrini MC.
Methods Mol Biol. 2018;1749:279-289. doi: 10.1007/978-1-4939-7701-7_20.

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis.
Nicol B, Salou M, Vogel I, Garcia A, Dugast E, Morille J, Kilens S, Charpentier E, Donnart A, Nedellec S, Jacq-Foucher M, Le Frère F, Wiertlewski S, Bourreille A, Brouard S, Michel L, David L, Gourraud PA, Degauque N, Nicot AB, Berthelot L, Laplaud DA.
J Autoimmun. 2018 Mar;88:61-74. doi: 10.1016/j.jaut.2017.10.005. Epub 2017 Oct 18.

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, Lelièvre Y, Casanova M, Vallot C, Nedellec S, Flippe L, Firmin J, Song J, Charpentier E, Lammers J, Donnart A, Marec N, Deb W, Bihouée A, Le Caignec C, Pecqueur C, Redon R, Barrière P, Bourdon J, Pasque V, Soumillon M, Mikkelsen TS, Rougeulle C, Fréour T, David L; Milieu Intérieur Consortium.
Nat Commun. 2018 Jan 24;9(1):360. doi: 10.1038/s41467-017-02107-w



2017

Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors.
Hached F, Vinatier C, Pinta PG, Hulin P, Le Visage C, Weiss P, Guicheux J, Billon-Chabaud A, Grimandi G.
Stem Cells Int. 2017;2017:9303598. doi: 10.1155/2017/9303598. Epub 2017 Oct 11

Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells.
Faucon A, Benhelli-Mokrani H, Fleury F, Dutertre S, Tramier M, Boucard J, Lartigue L, Nedellec S, Hulin P, Ishow E.
Nanoscale. 2017 Nov 14. doi: 10.1039/c7nr06533g.

Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after Pseudomonas Challenge in IL-12 Primed Natural Killer Cells.
Vourc'h M, Roquilly A, Broquet A, David G, Hulin P, Jacqueline C, Caillon J, Retiere C, Asehnoune K.
Front Immunol. 2017 Oct 10;8:1283. doi: 10.3389/fimmu.2017.01283. eCollection 2017.

Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines. Gonçalves C, Gomez JP, Même W, Rasolonjatovo B, Gosset D, Nedellec S, Hulin P, Huin C, Le Gall T, Montier T, Lehn P, Pichon C, Guégan P, Cheradame H, Midoux P. Eur J Pharm Biopharm. 2017 Aug;117:168-181. doi: 10.1016/j.ejpb.2017.04.015. Epub 2017 Apr 17.

PEGylated Anionic Magnetofluorescent Nanoassemblies: Impact of Their Interface Structure on Magnetic Resonance Imaging Contrast and Cellular Uptake. Linot C, Poly J, Boucard J, Pouliquen D, Nedellec S, Hulin P, Marec N, Arosio P, Lascialfari A, Guerrini A, Sangregorio C, Lecouvey M, Lartigue L, Blanquart C, Ishow E.ACS Appl Mater Interfaces. 2017 Apr 26;9(16):14242-14257. doi: 10.1021/acsami.7b01737. Epub 2017 Apr 17

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. Pouliquen DL, Nawrocki-Raby B, Nader J, Blandin S, Robard M, Birembaut P, Grégoire M. Oncotarget. 2017 Feb 25. doi: 10.18632/oncotarget.15744

Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes. Paul-Gilloteaux P, Potiron V, Delpon G, Supiot S, Chiavassa S, Paris F, Costes SV. Sci Rep. 2017 May 23;7(1):2280. doi: 10.1038/s41598-017-01757-6.

eC-CLEM: A multidimension, multimodel software to correlate intermodal images with a focus on light and electron microscopy. Heiligenstein X, Paul-Gilloteaux P, Raposo G, Salamero J. Methods Cell Biol. 2017;140:335-352. doi: 10.1016/bs.mcb.2017.03.014. Epub 2017 Apr 19

L. fermentum CECT 5716 prevents stress-induced intestinal barrier dysfunction in newborn rats. Vanhaecke T, Aubert P, Grohard PA, Durand T, Hulin P, Paul-Gilloteaux P, Fournier A, Docagne F, Ligneul A, Fressange-Mazda C, Naveilhan P, Boudin H, Le Ruyet P, Neunlist M. Neurogastroenterol Motil. 2017 Mar 31.

Autologous fat grafting: A comparative study of four current commercial protocols. Hivernaud V, Lefourn B, Robard M, Guicheux J, Weiss P. J Plast Reconstr Aesthet Surg. 2017 Feb;70(2):248-256

eC-CLEM: flexible multidimensional registration software for correlative microscopies. Paul-Gilloteaux P, Heiligenstein X, Belle M, Domart MC, Larijani B, Collinson L, Raposo G, Salamero J. Nat Methods. 2017 Jan 31;14(2):102-103

2016

Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions. Gavlovsky PJ, Tonnerre P, Gérard N, Nedellec S, Daman AW, McFarland BJ, Charreau B. J Immunol. 2016 Jun 24. pii: 1501416.

Pro-osteoclastic In Vitro Effect of Polyethylene-like Nanoparticles: Involvement in the Pathogenesis of Implant Aseptic Loosening. Brulefert K, Córdova LA, Brulin B, Faucon A, Hulin P, Nedellec S, Gouin F, Passuti N, Ishow E, Heymann D. J Biomed Mater Res A. 2016 Jun 2

Vitrectomy prior to intravitreal injection of AAV2/2 vector promotes efficient transduction of retinal ganglion cells in dogs and non-human primates Tshilenge KT, Ameline B, Weber M, Mendes-Madeira A, Nedellec S, Biget M, Provost N, Libeau L, Blouin V, Deschamps JY, Le Meur G, Colle MA, Moullier P, Pichard V, Rolling F. Hum Gene Ther Methods. 2016 May 26

Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine. Roulois D, Deshayes S, Guilly MN, Nader JS, Liddell C, Robard M, Hulin P, Ouacher A, Le Martelot V, Fonteneau JF, Grégoire M, Blanquart C, Pouliquen DL.Oncotarget. 2016 Apr 25

Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. Silva VA, Lafont F, Benhelli-Mokrani H, Breton ML, Hulin P, Chabot T, Paris F, Sakanyan V, Fleury F. Int J Mol Sci. 2016 May 11;17(5)

Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection. Ville S, Poirier N, Branchereau J, Charpy V, Pengam S, Nerriere-Daguin V, Le Bas-Bernardet S, Coulon F, Mary C, Chenouard A, Hervouet J, Minault D, Nedellec S, Renaudin K, Vanhove B, Blancho G. J Am Soc Nephrol. 2016 May 9.

 

Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis. Salou M, Nicol B, Garcia A, Baron D, Michel L, Elong-Ngono A, Hulin PNedellec S, Jacq-Foucher M, Le Frère F, Jousset N, Bourreille A, Wiertlewski S, Soulillou JP, Brouard S, Nicot AB, Degauque N, Laplaud DA. Clin Immunol. 2016 Apr 2

Stereotaxic administrations of allogeneic human V9V2 T cells efficiently control the development of human glioblastoma brain tumors. Jarry U, Chauvin C, Joalland N, Léger A, Minault S, Robard M, Bonneville M, Oliver L, Vallette FM, Vié H, Pecqueur C, Scotet E. Oncoimmunology. 2016 Mar 30;5(6):e1168554

Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation. Pabois A, Pagie S, Gérard N, Laboisse C, Pattier S, Hulin P, Nedellec S, Toquet C, Charreau B. Biochem Pharmacol. 2016 Jan 28

Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sakanyan V, Hulin P, Alves de Sousa R, Silva VA, Hambardzumyan A, Nedellec S, Tomasoni C, Logé C, Pineau C, Roussakis C, Fleury F, Artaud I. Sci Rep. 2016 Feb 17 

AAV-mediated gene therapy halts retinal degeneration in PDE6-deficient dogs.Pichard V, Provost N, Mendes-Madeira A, Libeau L, Hulin P, Tshilenge KT, Biget M, Ameline B, Deschamps JY, Weber M, Le Meur G, Colle MA, Moullier P, Rolling F. Mol Ther. 2016 Feb 9

2015

Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages?
Faucon A, Benhelli-Mokrani H, Córdova LA, Brulin B, Heymann D, Hulin P, Nedellec S, Ishow E.
Adv Healthc Mater. 2015 Nov 9.

Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response.
Achard C, Boisgerault N, Delaunay T, Roulois D, Nedellec S, Royer PJ, Pain M, Combredet C, Mesel-Lemoine M, Cellerin L, Magnan A, Tangy F, Grégoire M, Fonteneau JF.
Oncotarget. 2015 Nov 2

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.

Martin JC, Bériou G, Heslan M, Bossard C, Jarry A, Abidi A, Hulin P, Ménoret S, Thinard R, Anegon I, Jacqueline C, Lardeux B, Halary F, Renauld JC, Bourreille A, Josien R.
Mucosal Immunol. 2015 Sep 2.

3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds.

Brennan MÁ, Renaud A, Gamblin AL, D'Arros C, Nedellec S, Trichet V, Layrolle P.

Biomed Mater. 2015 Aug 4;10(4):045019.

Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.

Salou M, Garcia A, Michel L, Gainche-Salmon A, Loussouarn D, Nicol B, Guillot F, Hulin P, Nedellec S, Baron D, Ramstein G, Soulillou JP, Brouard S, Nicot AB, Degauque N, Laplaud DA.
Ann Clin Transl Neurol. 2015 Jun;2(6):609-22.

2014


Protein content and methyl donors in maternal diet interact to influence the proliferation rate and cell fate of neural stem cells in rat hippocampus.
Amarger V, Lecouillard A, Ancellet L, Grit I, Castellano B, Hulin P, Parnet P.
Nutrients. 2014 Oct 14;6(10):4200-17

Osteoblastic and osteoclastic differentiation of human mesenchymal stem cells and monocytes in a miniaturized three-dimensional culture with mineral granules.
Gamblin AL, Renaud A, Charrier C, Hulin P, Louarn G, Heymann D, Trichet V, Layrolle P.
Acta Biomater. 2014 Dec;10(12):5139-47
 

IL-15.IL-15R complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.
Tamzalit F, Barbieux I, Plet A, Heim J, Nedellec S, Morisseau S, Jacques Y, Mortier E.
Proc Natl Acad Sci U S A. 2014 Jun 10;111(23)
 

Mesenchymal stromal cells encapsulation in innovative biomaterials: application to osteoarthritis treatment.
Hached, P-G. Pinta, G. Rethore, C. Vinatier, N. Maillard, P. Hulin, P. Weiss, G. Grimandi, J. Guicheux, A. Billon-Chabaud
Osteoarthritis and Cartilage, Vol. 22, S444 : April, 2014
 

Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway. 
Le Dréan G, Haure-Mirande V, Ferrier L, Bonnet C, Hulin P, de Coppet P, Segain JP.

FASEB J. 2014 Mar;28(3):1059-70


LIMLE, a new molecule over-expressed following activation, is involved in the stimulatory properties of dendritic cells.
Le Texier L, Durand J, Lavault A, Hulin P, Collin O, Le Bras Y, Cuturi MC, Chiffoleau E.
PLoS One. 2014 Apr 4;9(4)

Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1. Ménager J, Ebstein F, Oger R, Hulin P, Nedellec S, Duverger E, Lehmann A, Kloetzel PM, Jotereau F, Guilloux Y.
PLoS One. 2014 Feb 27;9(2)

Highly Cohesive Dual Nanoassemblies for Complementary Multiscale Bioimaging.
Adrien Faucon, Thomas Maldiney,  Olivier Clément,  Philippe Hulin, Steven Nedellec, Myriam Robard, Nicolas Gautier, Evelien De Meulenaere, Koen Clays, Tomas Orlando, Alessandro Lascialfari, Céline Fiorini-Debuisschert, Jérôme Fresnaisj and Eléna Ishow.
Journal of Materials Chemistry B, 2014

2013

Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells.
Dilek N, Poirier N, Hulin P, Coulon F, Mary C, Ville S, Vie H, Clémenceau B, Blancho G, Vanhove B.
PLoS One. 2013 Dec 23;8(12)

Impaired Spatial Memory in Mice Lacking CD3 Is Associated with Altered NMDA and AMPA Receptors Signaling Independent of T-Cell Deficiency.
Louveau A, Angibaud J, Haspot F, Opazo MC, Thinard R, Thepenier V, Baudouin SJ, Lescaudron L,Hulin P, Riedel CA, Boudin H.
J Neurosci. 2013 Nov 20;33(47):18672-85
 

Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting.
Birklé S, Desselle A, Chaumette T, Gaugler MH, Cochonneau D, Fleurence J, Dubois N, Hulin P, Aubry J, Paris F.
Oncoimmunology. 2013 Apr 1;2(4)

LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets -parvin to control cell adhesion and migration.
Devallière J, Chatelais M, Fitau J, Gérard N, Hulin P, Velazquez L, Turner CE, Charreau B.
FASEB J. 2012 Jun;26(6):2592-606.

Photoactive chelating organic nanospheres as central platforms of bimodal hybrid nanoparticles

Adrien Faucon,  Jérôme Fresnais,  Arnaud Brosseau,  Philippe Hulin, Steven Nedellec, Julie Hemeza and Elena Ishow   
J. Mater. Chem. C, 2013,1, 3879-3886

Repeated systemic administrations of both aminobisphosphonates and human V9V2 T cells efficiently control tumor development in vivo.

Santolaria T, Robard M, Léger A, Catros V, Bonneville M, Scotet E.
J Immunol. 2013 Aug 15;191(4):1993-2000

2012

The molecular basis for modulation of human V9V2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specfic antibodies.

Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ.

J Biol Chem. 2012 Sep 21;287(39):32780-90. Epub 2012 Jul 30.

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human T-cell subset.

Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J, Li J, Kuball J, Adams EJ, Netzer S, Déchanet-Merville J, Léger A, Herrmann T, Breathnach R, Olive D, Bonneville M, Scotet E.

Blood. 2012 Sep 13;120(11):2269-79.
 

HLA-E-restricted cross-recognition of allogeneic endothelial cells by CMV-associated CD8 T cells: a potential risk factor following transplantation.

Allard M, Tonnerre P, Nedellec S, Oger R, Morice A, Guilloux Y, Houssaint E, Charreau B, Gervois N.

PLoS One. 2012;7(11)

Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis.

Coupé B, Grit I, Hulin P, Randuineau G, Parnet P.

PLoS One. 2012;7(1)
 

Functional interaction between CFTR and the sodium-phosphate co-transport type 2a in Xenopuslaevis oocytes.

Bakouh N, Chérif-Zahar B, Hulin P, Prié D, Friedlander G, Edelman A, Planelles G.

PLoS One. 2012;7(4)

Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development.

Desselle A, Chaumette T, Gaugler MH, Cochonneau D, Fleurence J, Dubois N, Hulin P, Aubry J, Birklé S, Paris F.

PLoS One. 2012;7(11)
 

Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction.

Mathieu E, Lamirault G, Toquet C, Lhommet P, Rederstorff E, Sourice S, Biteau K, Hulin P, Forest V, Weiss P, Guicheux J, Lemarchand P.

PLoS One. 2012;7(12):e51991. doi: 10.1371/journal.pone.0051991. Epub 2012 Dec 20.